210 / 604
Dose of
dexamethasone
?
Study A
Day 7
Day 28
Dexa 8 mg
8.0 (+/-10.1)
Dexa 16 mg
7.3 (+/-14.2)
Study B
Day 7
Day 28
Dexa 4 mg
6.7 (+/-11.3)
7.1 +/- 18.2
Dexa 16 mg
9.1 (+/-12.4)
5.6 +/- 18.5
Randomized, double blinded study
Improvement in Karnofski score (mean +/- SD)
Vecht et al Neurology 44(4): 675; 1994
N=96
Loading dose not based on evidence, but
it does not cause serious side effects