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Leucoencephalophaty after WBRT
12 patients 5-36 mts. after WBRT
•
progressive dementia
•
ataxia
•
urinary incontinence
•
severe disability
•
7 deaths
67 year-old woman treated with
PCI 30 Gy/15 frx for SCLC in 2006.
SRS for isolated recurrence may 2008.
Reduced memory in 2008.
Progressive dementia thereafter
(hospice 2010).
Sahgal et al. Prog Neurol Surg 2012; 25: 82
DeAngelis et al. Neurology 1989;39:789