326 / 604
The Patchell-Study
randomized trial, stopped after interim analysis
(Patchell, Lancet,
2005)
surgery plus 10 x 3 Gy (N=50) vs. 10 x 3 Gy alone
(N=51)
ability to walk after treatment:
42/50 (84%) vs. 29/51 (57%), p=0.001
maintaining ambulatory status for:
median 122 vs. 13 days, p=0.003
Surgery only for selected patients (10-15%):
KPS
70 , OS
3 mos., no paraplegia > 48 hrs., 1 spinal segment, no
myeloma
•
10 years to accrue
(not all eligible patients included?)
•
10% more ambulatory
patients than in other series
•
small number
of patients (statistical power?)