80 / 604
Some authors suggest
Morfine slow release 5mg po x2/d
Uptitrate to 1-2,5 mg po/4h by the end of the first week
Doses are uptitrated by 25% weekly until adequate symptom relief is achieved
Other authors use sustained release morphine
Starting dose 10 mg/d and titrated weekly to 20 or 30 mg/d without respiratory
depression or significant side effects
è
Compliance is highest with once daily dosing or patch/3 days