850 / 1359
Dose (Gy)
−D
TL
+D
TL
Step 3:
Adjust the
true dose probability distribution
such that the dose
limits
IDC-C
a
/2
and
IDC+C
a
/2
coincide with the
clinical tolerance
limits.
Prescribed dose
Clinical tolerance
limits
is set to a minimum
acceptable cure rate
is set to a maximum
acceptable complication rate
Probability distribution
for the true dose
Action limits - Proposed philosophy