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Investigated peptide/protein oxidative side-reaction in CuAAC reaction by combinatorial
peptide synthesis and MS-based protein modification analysis. Discovered a new type of
copper-binding ligand to significantly reduce peptide/protein oxidative degradation and
accelerate CuAAC reaction. Developed a new catalyst for CuAAC bioconjugation reaction
inside living mammalian cells. Studied the intracellular reaction by MS-based quantitative
analysis, immunofluorescence and immunoblotting assays. Identified a key inhibitor for
intracellular CuAAC reaction.
AWARDS & MEMBERSHIPS
2010-2015
DSTF Fellowship, UH
2010
Outstanding Senior Student, SCUT
2009-2010
Undergraduate Research Fellowship, SCUT
American Society for Mass Spectrometry (ASMS)
Association of Official Analytical Chemists (AOAC)
OTHER ACTIVITIES
Scientific reviewer for
Molecules
,
International Journal of Molecular Sciences
,
Chemistry &
Biodiversity
,
Materials Chemistry and Physics
,
Chemical Biology & Drug Design
.
PUBLICATIONS
1.
Li, S.
, Wang, L., Yu, F., Zhu, Z., Shobaki, D., Chen, H., Wang, M., Wang, J., Qin, G., Erasquin,
U., Ren, L., Wang, Y. and Cai, C. Copper-catalyzed click reaction on/in live cells.
Chem. Sci.
,
2017
, 8, 2107–2114.
2. Zhu, Z., Chen, H.,
Li, S.
, Yang, X., Bittner, E. and Cai, C. Tripodal amine ligands for
accelerating Cu-catalyzed azide-alkyne cycloaddition: efficiency and stability against oxidation
and dissociation.
Catal. Sci. Technol.
,
2017
, 7, 2474–2485.
3. Chen, H., Cai, C.,
Li, S.
, Ma, Y., Luozhong, S. and Zhu, Z. Intermediates stabilized by
tris(triazolylmethyl)amine in CuAAC reaction.
Eur. J. Chem.
,
2017
, 23, 4730–4735.
4. Chen, Q., Zhu, Z., Wang, J., Lopez, A.,
Li, S.
, Kumar, A., Yu, F., Chen, H., Cai, C. and Zhang,
L. Probiotic E.Coli Nissle 1917 biofilms on silicone substrates for bacterial interference against
pathogen colonization.
Acta Biomater.
,
2017
, 50, 353–360.
5. Qin, G., Zhu, Z.,
Li, S.
, McDermott, A. and Cai, C. Development of ciprofloxacin-loaded contact
lenses using fluorous chemistry.
Biomaterials
,
2017
, 124, 55–64.
6.
Li, S.
,
Cai, H., He, J., Chen, H., Lam, S., Cai, T., Bark, S. and Cai, C. Extent of the oxidative
side-reactions to peptides and proteins during CuAAC reaction.
Bioconjugate Chem.
,
2016
, 27,
2315–2322.
7. Qin, G., Zhu, Z.,
Li, S.
, Cai, C. and McDermott, A. Contact lens surface modification utilizing
fluorous chemistry.
Invest. Ophthalmol. Vis. Sci.
,
2016
, 57, 1458–1458.
8. Contreras-Caceres, R., Santos, C.,
Li, S.
, Kumar, A., Zhu, Z., Kolar, S., Casado-Rodriguez, M.,
Huang, Y., McDermott, A., Lopez-Romero, J. and Cai, C. Modification of fluorous substrates
with oligo(ethylene glycol) via “click” chemistry for long-term resistance of cell adhesion.
J.
Colloid Interface Sci.
,
2015
, 458, 112–118.
9. Zhu, Z., Wang, J., Lopez, A., Yu, F., Huang, Y., Kumar, A.,
Li, S.
, Zhang, L. and Cai, C.
Surfaces presenting α-phenyl mannoside derivatives enable formation of stable, high coverage,
non-pathogenic Escherichia coli biofilms against pathogen colonization.
Biomater. Sci.
,
2015
, 3,
842–851.
10. Wang, L., Zhao, M.,
Li, S.
, Erasquin, U., Wang, H., Chen, C. and Cai, C. “Click” immobilization
of a VEGF-mimetic peptide on decellularized endothelial extracellular matrix to enhance
angiogenesis.
ACS Appl. Mater. Interfaces
,
2014
, 6, 8401–8406.