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Prescribed dose

Dose (Gy)

Clinical tolerance

limits

TL



TL

Action limits - Proposed philosophy

Step 3: Adjust the

true dose probability distribution

such that the

dose limits

IDC-C

/2

and

IDC+C

/2

coincide with the

clinical

tolerance limits.

is set to a minimum

acceptable cure rate

is set to a maximum

acceptable complication rate

Probability distribution

for the true dose