147 / 236
Bacterial repopulation after surgery & antibiotics
FIGURE 4.
PCoA of microbial communities. PCoA was performed on genus-level microbiome data using Morisita-Horn similarity scores calculated on each
pair of samples. The top 3 plots show the distribution of samples along PC1-PC2, PC1-PC3, and PC2-PC3. Baseline, 2-week, and 6-week samples are designated
by circles, squares, and triangles, respectively. Each subject is designated by a unique color. The bottom 12 plots display the PC1-PC2 plots for individual
subjects. ESS
=
endoscopic sinus surgery; PCoA
=
principal coordinates analysis.
complex interplay between the microbiome and therapeu-
tic interventions.
Conclusion
Bacterial communities colonizing the ethmoid at 6 weeks
postoperatively were most similar to anterior nasal cavity
and pretreatment sinus microbial profiles, indicating the
resilience of these sites and suggesting they may be poten-
tial sources for repopulation of bacteria postoperatively.
Bacterial communities appear to largely return to their nor-
mal preoperative state, with some degree of interpersonal
variation, identifying another variable that could affect
therapeutic outcomes. Interestingly, postoperative antibi-
otic therapy did not reduce the bacterial burden, but rather
shifted the microbial consortia.
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