200 / 236
TABLE III.
Characteristics of Included Studies by Endoscopic Reconstruction Type (Free Grafting).
Study
Year
Study Focus, Flap or Pathology
No.
No. With
Defect
Repair
Type
Age (SD
or Range)
% Female
Defect Size
(Longest Axis)
Defect
Location
Lumbar
Drain
Use, % (Days)
Prior
Radiotherapy, %
Batra
16
2010 Mixed benign and malignant neoplasms 31 17
Free 57.5 (14–84)
42
16 mm F, E, P
47
19
Cavallo
18
2007 Suprasellar: Men, CP, AD, RC, glioma
21 21
Free
NR
NR
NR
P
5 (7)
5
Chen
20
2006 Mixed malignant neoplasms
7
1
Free 52.7 (33–79)
29
NR
E, P
NR
NR
Church
21
2003 Iatrogenic post-ESS defects
3
3
Free 43.7 (10.6)
0
>
20 mm E, P
67
0
de Divitiis
23
2007 Suprasellar: Men, CP, AD, RC, AC
20 20
Free 49.5 (24–70)
55
NR
P
15
NR
de Divitiis
22
2007 Craniopharyngioma
10 10
Free 57.2 (26–70)
40
52.8 mm
2
P
NR
NR
de Divitiis
24
2007 Meningioma
6
6
Free 56.1 (44–70)
50
24.7 mm P
0
0
El-Banhawy
27
2008 Meningioma (from mixed group)
3
3
Free 42.5 (40–45)
0
14 mm E, P
NR
NR
Esposito
9
2007 Mixed: Men, CP, AD, Ch, RC,
malignant neoplasms
620 58
Free 46 (5–86)
59
NR
P, C
100
NR
Gardner
1
2008 Meningioma
35 35
Free 55 (39–79)
83
NR
E, P
100
6
Germani
32
2007 Mixed benign and malignant
neoplasms, CSF leak
56 55
Free
NR
NR 29% 4–20 mm,
29%
>
20 mm
E, P
20
NR
Horiguchi
35
2010 Control patients: free grafts
11 10
Free 52 (27–79)
27
NR
E, P, C
90
NR
Kassam
36
2007 Mixed benign and malignant
neoplasms, CSF leak
25 11
Free 11.9 (5.3)
52
NR
E, P, C
NR
NR
Laufer
38
2007 Suprasellar: Men, CP, RC
10 10
Free 54 (12.4)
NR
26.5 mm P
50
NR
Leng
39
2008 Mixed: Men, CP, Ch, CSF leak
10 10
Free
NR
NR
NR
E, P, C
50
10
Leong
40
2006 Mixed benign and malignant
neoplasms
14 10
Free 57.4 (26–84)
43
4–40 mm E, P
70 (5)
29
Luginbuhl
41
2010 Control patients: free grafts
24 24
Free
NR
NR
17 mm E, P, C
33
NR
Stamm
46
2008 Craniopharyngioma: free grafts
3
3
Free 23.4 (16.3)
33
NR
P
0
NR
Vergez
47
2009 Adenocarcinoma
17
5
Free 68 (44–82)
0
NR
C, P
NR
NR
Villaret
48
2010 Mixed malignant neoplasms
62 14
Free 61.7 (25–84)
29
NR
E, P
47
19
F
¼
transfrontal; E
¼
transethmoid/cribriform; P
¼
transplanum; CP
¼
craniopharyngioma; AD
¼
adenoma; RC
¼
Rathke’s cyst;, NR
¼
not reported; ESS
¼
endoscopic sinus surgery; AC
¼
astrocytoma;
Ch
¼
chordoma; C
¼
transclival; CSF
¼
cerebrospinal fluid; Men
¼
meningioma.
Laryngoscope 122: February 2012
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