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Adulteration of Dietary Supplements with 

Synthetic PDE5 Inhibitors

Serious problem 

Potential serious adverse (even lethal) health affects

Adulteration with approved drugs but also their 

unapproved analogs (unknown toxicological effects)

High incidence of adulteration

Campbell

et al

., 

J. Sex. Med.

10 (2013) 1842‐1849:

81%

out of 91 tested

herbal products adulterated 

with synthetic PDE5 inhibitors and their analogs