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Version 1.1
AOAC QUALITATIVE STUDY STATISTICAL REVIEW CHECKLIST
DOCUMENT ID: ______________________________________________________
Approve __ Changes needed, no review __ Changes needed, new review __ Reject __
(Place ‘N’ beside any of the below where a defect is found.)
TITLE:
1. __ Is the analyte stated?
2. __ Is the AOAC method identifier stated?
3. __ Is the type of study described (PTM vs. SLV vs. MLV, etc.)?
ABSTRACT:
4. __ Are required measures of effect reported, along with 95% confidence intervals?
5. __ Are results reported separately for each matrix?
6. __ Are results reported for repeatability and reproducibility with 95% confidence
intervals?
7. __ Is the use of unjustified compositing across matrices or collaborators avoided?
8. __ Are any hypothesis test results reported in proper form and is the observed confidence
interval on measure of effect used to assess any conclusion drawn?
9. __ Is the study identified as matched (paired) or unmatched (unpaired) in methods to
replicates?
10. __ Are the reported results free of improper generalization?
INTRODUCTION:
11. __ Is the current state of the art for the same analyte and matrices properly reviewed?
12. __ Is the previous history of the candidate method reviewed?
METHOD & MATERIALS:
13. __ Are the matrices unambiguously defined sufficiently to allow reproduction of the
study?
14. __ Are the sampling and method of preparation described adequately?
15. __ Is the mixing of the samples homogeneous, and is there validation given for this?
16. __ Is the method of removal of test portions precisely defined so as to indicate preclusion
of possible correlation of results?
17. __ Are outliers excluded solely for physical cause, which has been identified and
supported by objective proof?
18. __ Are the required minimum number of replicates performed?
19. __ Are the required minimum number of collaborators used?
20. __ Is the study identified as matched (paired) or unmatched (unpaired) in methods to
replicates?
21. __ Are the test portion replicates adequately randomized and masked with respect to
preparation and distribution to collaborators?