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Chordoma Chondrosarcoma
03/01/13
Chordoma: Radiation
•
The primary role of radiation therapy following maximal surgical resection
is to improve local control
•
There have been no randomized studies investigating optimal dose
•
Initial results in the 1960s and 1970s suggest an improvement in
symptomatic response and local control with increasing dose
•
Used antiquated techniques and often included multiple sites in their
reports
•
In 1970 Pearlman and Friedman: Decrease in local failure with
↑
dose
Dose
Rates of Failure
<40 Gy (n=47)
85%
40 – 60 Gy (n=18)
60%
60-80 Gy (n=8)
43%
>80 Gy (n=2)
0%