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Chordoma Chondrosarcoma
03/01/13
Ares
et al
. IJROBP 2009;75(4):1111-8
Prognostic Factors Significant for Local Control in CHORODMA
•
Residual tumor volume >25 c.c.
•
Brainstem compression
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Radiation-induced Late Toxicity
(CTCAE v3.0)
•
Asymptomatic MRI white matter changes (G1) = 5 patients
•
High grade late toxicity = 4 patients (all diagnosed with chordoma)
- optic pathway:
G4 (1 patient) – unilateral blindness
G3 (1 patient) – unilateral visual deficit, steroid
dependent
- neurologic: G3 (2 patients) –
symptomatic brain necrosis
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Actuarial 5-year freedom from high-grade toxicity: 94%