0
6
12
18
24
Time (months)
100
80
60
40
20
0
Survival
(%)
WBRT + SRS
WBRT alone
WBRT + SRS
WBRT alone
100
80
60
40
20
Local progression free survival
(%)
WBRT
WBRT alone
local control
survival
WBRT +/- radiosurgery for brain metastases
WBRT whole brain RT
SRS stereotactic
radiosurgery
RTOG 9508
Andrews
et al 2004, Lancet; 363: 1665–72