In patients with non-small cell lung cancer and brain metastases
1. at presentation (stage IV disease) radiotherapy
is the best treatment
2. chemotherapy is the best treatment in patients with
poor performance status
3. in ALK mutated adenocarcinoma
crizotinib is the appropriate treatment
4. in ALK mutated adenocarcinoma
crizotinib prolongs survival compared to whole brain RT
5. none of these