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Brain necrosis Introduction
•
Coagulation necrosis
•
Vascular Thickening
•
Peri-vascular fibrosis
•
Infiltartion of chr inflammatory cells
Therory
1.
Vascular hypothesis
: lesions of small to medium vessels, necrosis is
secondary to ischemia.
2.
Glial hypothesis
: irradiation damage glial cells (oligodendrocytic +++)
leading to white matter cavitation and demylenisation
3.
Immunologic hypothesis
: radiation necrosis and vascular change in
response to Ag release from damaged glial cells
03/01/13