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Inactivation of MGMT gene by promoter methylation
„Responder“
„Non-Responder“
unmethylated
MGMT
promotor
MGMT
gene
Transcription/translation
MGMT
promotor
active
Chemo-
resistance
MGMT
gene
Transcription/translation
CH
3
CH
3
CH
3
CH
3
CH
3
MGMT
promotor
MGMT
promotor methylation
inactive
Chemosen-
sitivity