Lynch et al. N Engl J Med 2004
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Matsumoto et al. Int J Cancer 2006
Park et al. Lung Cancer 2012
Maemondo et al. N Engl J Med 2010
Rosell et al. Lancet Oncol 2012
• Activating EGFR mutations particularly commmon in
adenocarcinomas of the lung
• EGFR mutations may be overrepresented in brain mets
of lung cancer patients
• Clinical activity of EGFR inhibitors in patients with
activating EGFR mutations has been shown in several
large trials
• Modest BBB penetration of EGFR inhibitors
EGFR inhibitors