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WBRT MAY NEGATIVELY IMPACT HEALTH-RELATED
QUALI TY OF LIFE (HRQL) IN BRAIN METASTASIS
• Increasing interest for HRQL as an endpoint for treatment
comparisons in many cancer types, especially in advanced
stages
(
Bottomley et al, Eur J Cancer 2005
)
• After PCI for SCLC significant, but reversible, short-term (3
months) negative impact on selected HRQL scales, such as
fatigue, hair loss, or cognitive functioning
(
Slotman et al, JCO 2009
).
• After PCI for NSCLC significant decline in memory at 1 year
(
Sun
et al, JCO 2011
)
• No data available so far regarding the impact of adjuvant WBRT
on HRQL of patients with brain metastases.