52 / 1266
Classical
Proneural
Mesenchymal
Neural
Cr 7 Ampl
Cr 10 loss
p16 deletion
IDH1 mut
p53 mut
PDGFRA mut
NF1 del
YKL-40 expr
Met expr
Neuron
markers
expression
grade III/IV
Grade IV
No necrosis
Necrosis
Inflammation
Younger (<40y)
older
better OS
poor OS
Verhaak R. et al 2010 and Phillips et al. 2006
same histology and grade BUT
different prognosis
Secondary GBM
The molecular background