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General strategy in diagnosis and management
Europ. Consensus SIOP CNS GCT
Germinoma
If tumour markers are negative or slightly elevated,
a histological diagnosis is mandatory
Secreting germ cell tumours
If tumor markers αFP and/or βHCG are elevated
(αFP > 25 ng/ml; βHCG > 50 IU/L)
and imaging shows a characteristic lesion,
a secreting germ cell tumour is diagnosed
and treatment should be started with chemotherapy
(without histological confirmation)
Intracranial germ cell tumours (GCT)