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Lower-grade gliomas
with an
IDH
mutation and 1p/19q codeletion
were of
the
oligodendroglioma
histologic class
and were associated with
favorable
outcomes
.
Tumors with
wild-type IDH
were
molecularly and clinically distinct from
subtypes with mutated IDH
, with most
showing a striking resemblance to
primary
glioblastoma
on all analytic platforms
It may transpire that
distinct therapeutic
strategies
are required for effective disease
control in molecular subtypes of lower-grade
glioma.
Handling
Histo-molecular
criteria