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SIOP CNS GCT II
Underlying philosophy:
Convert macroscopic to subclinical disease
by using chemotherapy before RT
Dose reduction from 40 to 24 Gy (primary tumour site)
(Japanese data, : overall tumor-free rate 92.9% (52 of 56 pat.)
Med.f-up, 2.1 years, 1 relapse outside RT area. Matsutani et al., 1998
Dose reduction to non-target brain
(dose reduction to functionally relevant areas)
Reduction of risk for late effects
SIOP CNS GCT II / new study / germinoma