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High Grade Glioma: Aetiology
• In most cases is unknown
• Previous radiation treatment
• Genetic disease
- Neurofibromatosis type I: mutation in the NF-1
- Li-Fraumeni Syndrome: defect in TP53
- Turcot syndrome: defect in the APC gene and/or a mutation
in DNA mismatch repair (MMR) genes
- Mismatch repair deficiency of the MSH6 mismatch repair