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Define a common backbone

!

At present for pHGG & aHGG

Chemo-radiotherapy with temozolomide

DIPG- radiotherapy only

Common shared targets?

Majority express target

Histone

H3F3

as common target pHGG &

DIPG?

High target presence in both pHGG and aHGG?

E.g. ?VEGFR/ Integrins/ immunotherapy