771 / 1266
Frequency of BRAF mutations
•
~8% of all Cancers
•
100% Hairy Cell Leukaemia
•
50% of Melanoma
•
45% Papillary Thyroid Cancer
•
30% Borderline Ovarian Ca.
•
10% Colorectal Cancer
•
2% NSCL Cancer
Most common mutation (BRAF V600E)—substitution of valine with
glutamic acid at amino acid position 600 — locks BRAF into its active
conformation, which has at >10 x higher activity than WT-type BRAF