837 / 1266
Gandola L. et al, JCO, 27, 2009
Milan HART Study
- 1998-2007
- 33 pts (M1 9, M2 6, M3 17, M4 1)
- High dose chemotherapy approach
- HART: CSI 39 Gy; 1.3 Gy bid
posterior fossa boost up to 60 Gy; 1.5 Gy bid
- 7 pts aged < 10 yrs who achieved CT after chemo received a
lower dose to the neuraxis (31.2 Gy)
- Median 82 months follow-up
- 5 yr EFS 70%
- 5 yr PFS 72%
- 5 yr OS 73%