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Intraoperative stimulation mapping cinical
relevance
Meta-analysis including 8091 patients
De Witt Hamer PC, Gil Robles S, Zwinderman AH, et al.
Impact of & intraoperative stimulation brain mapping on
glioma surgery outcome: a meta-analysis.
J Clin Oncol 2012; 10:2559 – 2565.
“
Glioma resections using ISM are associated with fewer late severe
neurologic deficits and more extensive resection, and they involve
eloquent locations more frequently. This indicates that ISM should
be universally implemented as standard of care for glioma surgery
”
.
Late Severe Neurological Deficits
observed in 3.4% of ISM vs 8.2%