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A Phase 1 Study of AZD6244 in Children with Recurrent
or Refractory Low Grade Gliomas: A Pediatric Brain
Tumor Consortium Report
.
Toxicity
•
Dose limiting toxicities were headache, rash, mucositis, and elevation of
amylase and lipase
•
Maximum tolerated dosage = 25 mg/m2/dose
•
At dose levels above 25mg/m2/dose, toxicities resulted in treatment
discontinuation rate of 36
%