165 / 264
TABLE 2.
Study assessment
Relevance
Risk of Bias
Study (year)
No. of Patients
(No. of Ears)
Study
Population
Index
Test
Outcome
Overall
Relevance Selection
Blinding
of (IT)
Blinding
of (RT)
Standardization
(IT)
Standardization
(RT)
Missing
Data
Overall Risk
of Bias
Marx (2011) (16), Lagleyre
(2009) (17)
200 (209)
* * *
H
*
*
*
*
* *
M
Shin (2001a) (18)
NR (474)
* * *
H
* *
*
*
* *
M
Karosi (2012) (3)
57 (57)
*
* *
M
*
* *
*
* *
L
Liktor (2014) (2)
32 (32)
*
* *
M
*
* *
*
* *
L
Trojanowska (2007) (19)
90 (180)
*
* *
M
*
*
*
*
*
*
M
Kiyomizu (2004) (6)
44 (82)
*
* *
M
* *
*
*
*
*
M
Tringali (2007) (20)
NR (119)
*
* *
M
* *
*
*
*
*
M
Bozorg Grayeli (2004) (21)
10 (10)
*
* *
M
* *
*
*
*
*
H
Lee (2009) (22)
22 (24)
*
* *
M
* *
*
*
* *
H
Mori (2013) (23)
17 (27)
*
* *
M
* *
*
*
*
*
H
de Oliveira Vicente (2004) (24),
de Oliveira Vicente (2006) (25)
54 (108)
*
* *
M
* *
*
*
*
*
H
Berretini (2010) (26)
45 (90)
*
* *
M
* *
*
*
* *
H
Shin (2001b) (27)
NR (211)
*
* *
M
* *
*
*
* *
H
*
indicates satisfactory;
*
, not satisfactory or unclear; H, high; L, low; M, moderate; NR, not reported.
Relevance. Study population: adult patients suspected of otosclerosis. Index test: CT. Outcome: otosclerosis established during middle ear surgery.
Risk of bias. Selection: consecutive or random sample of patients selected without exclusion based on incompleteness of data. Blinding of index test (IT): outcome assessor blinded for CT
results. Blinding of reference test (RT): radiologist blinded for surgery outcome. Standardization of index test (IT): uniform protocol for performing and assessing CT. Standardization of reference
test (RT): uniform protocol for or uniform manner of establishing otosclerosis during middle ear surgery or histopathology. Missing data:
20% missing data.
I. WEGNER ET AL.
Otology & Neurotology, Vol. 37, No. 1, 2016
144