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Keeping things in perspective

• GTV

PTV margin

– No underdosage allowed

– Use margin prescription

• CTV

PTV margin

– In the CTV there is a probability of tumor cells

– Not clear what PTV margin to use

probabilistic approach

– Margin prescription probably too large

– CTV sometimes based on ‘anatomical’ borders (e.g. bone)

Margin prescription does not apply, or applies to the border