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© 2012 AOAC INTERNATIONAL
G
UIDELINES
FOR
S
TANDARD
M
ETHOD
P
ERFORMANCE
R
EQUIREMENTS
AOAC O
FFICIAL
M
ETHODS
OF
A
NALYSIS
(2012)
Appendix F, p. 6
Table A1. Performance requirements
Classifications of methods
a
Quantitative method
Qualitative method
Identification method
Main component
b
Trace or contaminant
c
Main component
b
Trace or contaminant
c
Parameter
Single-laboratory validation
Applicable range
Bias
d
Precision
Recovery
Limit of quantitation (LOQ)
Applicable range
Bias
d
Precision
Recovery
LOQ
Inclusivity/selectivity
Exclusivity/cross-reactivity
Environmental interference
Laboratory variance
Probability of detection
(POD)
e
Inclusivity/selectivity
Exclusivity/cross-reactivity
Environmental interference
Laboratory variance
POD at AMDL
f
Inclusivity/selectivity
Exclusivity/cross-reactivity
Environmental interference
Probability of identification
(POI)
Reproducibility
RSD
R
or target
measurement
uncertainty
RSD
R
or target
measurement
uncertainty
POD (0)
POD (c)
Laboratory POD
g
POD (0)
POD (c)
Laboratory POD
g
POI (c)
Laboratory POI
a
See Annex B
for additional information on classification of methods.
b
≥100 g/kg.
c
<100 g/kg.
d
If a reference material is available.
e
At a critical level.
f
AMDL = Acceptable minimum detection level.
g
LPOD = CPOD.