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Friday, February 26
Exhibitor Registration
8:00 am–5:00 pm, West Lobby
Drug Discovery Satellite Meeting XVI
8:00 am–5:00 pm, Room 411
Sponsored by Axiogenesis, Sophion together with Biolin Scientific, Cellular
Dynamics International, Charles River, Maxcyte Inc, Molecular Devices
LLC, Nanion Technologies GmBH
Ion channels are an important class of therapeutic drug targets, and mu-
tations in ion channel genes are found to be responsible for an increasing
number of diseases. While conventional electrophysiological techniques
permit the most detailed and direct study of ion channel function,
they are limited due to the manual nature of the method and their low
throughput. Because of this, ion channels remain an underrepresented
target class for drug discovery. But the advent of automated electro-
physiological systems with higher throughput has begun to revolutionize
ion channel drug discovery. This symposium focuses on the emerging
technology of automated electrophysiology and how it is changing the
face of ion channel drug discovery. Speakers from industry and academia
will discuss the development and potential of these new technologies,
present experimental results obtained using these systems and discuss
the impact these technologies are having on ion channel drug discovery.
Co-Chairs
Niels Fertig, Nanion Technologies GmbH
Jeff Webber, Molecular Devices LLC
Eugenia Jones, Cellular Dynamics International
Richard Kondos, Sophion – Biolin Scientific
7:30 am
registration
8:00 am
introduction
SESSION I
Chair, Niels Fertig
8:30 am
WETWARE IN THE LOOP: REALTIME MODELLING USING DYNAMIC CLAMP
FOR SAFETY AND DRUG DISCOVERY.
Steve Petrou
9:00 am
GIGASEAL AUTOMATED PATCH-CLAMP RECORDINGS OF ION CHANNEL
ACTIVITY EXPRESSED IN CELL LINES AND NATIVE CELLS.
Arturo Picones
9:30 am
NEXT GENERATION ELECTROPHYSIOLOGY: COMPARISON OF PLATFORMS
TO PROGRESS EFFICACY AND LIABILITY CAPABILITY AT ASTRAZENECA.
Matthew Bridgland-Taylor
10:00 am
break
SESSION II
Chairm, Jeff Webber
10:30 am
OPTICAL METHODS FOR EXAMINING EXCITATION-CONTRACTION COU-
PLING IN IPS-DERIVED CARDIOMYOCYTES AND THEIR APPLICATION TO
MEDIUM/HIGH THROUGH-PUT ASSAYS.
Godfrey Smith
11:00 am
IDENTIFICATION AND CHARACTERIZATION OF NOVEL NMDA RECEPTOR
POSITIVE ALLOSTERIC MODULATORS (PAMS).
David Hackos
11:30 am
AUTOMATED ELECTROPHYSIOLOGY FOR TRANSLATIONAL CARDIAC
MUSCLE.
Liudmila Polonchuk and Ken Wang
12:00 pm
lunch (provided)
SESSION III
Chair, Eugenia Jones
1:00 pm
THE COMBINED USE OF ION CHANNEL STUDIES AND HUMAN IPS-DE-
RIVED CARDIAC MYOCYTES IN PRECLINICAL SAFETY ASSESSMENT.
Alison Easter
1:30 pm
INVESTIGATION OF POTASSIUM CHANNEL FUNCTION UTLIZING HUMAN
iPSC-DERIVED NEURONS.
Matthew Fuller
2:00 pm
AUTOMATED PATCH CLAMP ASSAYS FOR STATES DEPENEDENT ION CHAN-
NEL MODULATORS.
Rok Cerne
2:30 pm
AUTOMATED ELECTROPHYSIOLOGY AS A PLATFORM FOR BIOPHYSICAL
CHARACTERIZATION AND ION CHANNEL DRUG DISCOVERY.
Sophia Lin
3:00 pm
break
SESSION
IV
Chair. Richard Kondo
3:30 pm
HUMAN iPS CELL-DERIVED CARDIOMYOCYTES AS A MODEL FOR CHARAC-
TERIZATION OF NEW LQT SYNDROMMUTATION.
Roselle Gélinas
4:00 pm
COUPLING HIGH CAPACITY ELECRROPORATION WITH AUTOMATED
PATCHY CLAMP RECORDING FOR FUNCTONAL ANNOTATION OF HUMAN
ION CHANNEL VARIANTS.
Alfred George
4:30 pm
Speaker to be announced
5:00 pm
closing remarks
Richard Kondo
New Council Orientation
3:00 pm - 4:30 pm, J.W. Marriott - Plaza III
Registration Open
3:00 pm - 5:00 pm, West Lobby
Joint Council Reception, Dinner, and Meeting
5:00 pm - 9:00 pm, J.W. Marriott - Plaza I & II