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42

PROGRAMME

| PROGRAMME AND EXHIBITION GUIDE

PRE-MEETING COURSES

Radiobiology track

CLINICAL APPLICATION OF NEWCOMBINATIONS: HOWTO TEST AND OPTIMISE

NOVEL BIOLOGICAL AGENTS IN COMBINATIONWITH RADIOTHERAPY

09:15 - 17:00 | LONDRA

Course Directors: A. Chalmers (UK) and D. Zips (Germany)

09:15

INTRODUCTION AND OVERVIEW

Course Director: A. Chalmers (UK)

09:30

INTRINSIC CELLULAR TARGETS, INCLUDING THE DNA DAMAGE

RESPONSE AND ONCOGENIC SIGNALLING PATHWAYS

A. Chalmers (UK)

10:00

TUMOUR MICROENVIRONMENT TARGETS, INCLUDING HYPOXIA,

VASCULATURE AND THE IMMUNE SYSTEM

R. Bristow (Canada)

10:30

COFFEEBREAK

11:00

PRECLINICAL EVALUATION OF NOVEL DRUG-RADIOTHERAPY

COMBINATIONS: IN VITRO AND EARLY IN VIVO TESTING

Teacher: C. Vens (The Netherlands)

11:30

PRECLINICAL EVALUATION OF NOVEL DRUG-RADIOTHERAPY

COMBINATIONS: COMPLEX IN VIVOMODELS

Teacher: M. Baumann (Germany)

12:00

CLINICAL TRIAL DESIGN: INCLUDING DOSE SELECTION, DOSE

ESCALATION AND BIOMARKER DRIVEN STUDY DESIGNS

Teacher: P. Lambin (The Netherlands)

12:30

DISCUSSION

13:00

LUNCH

14:00

MOLECULAR BIOMARKERS FOR OPTIMISATION OF NOVEL

RADIOTHERAPY-DRUG COMBINATIONS

Teacher: D.G. Duda (USA)

14:30

IMAGING BIOMARKERS FOR OPTIMISATION OF NOVEL

RADIOTHERAPY-DRUG COMBINATIONS

Course Director: D. Zips (Germany)

15:00

COFFEEBREAK