1324-1325 / 3107
SRS with or without WBRT in the treatment of patients with single or multiple brain metastases
Randomized trials # BM Study endpoint
SRS
SRS+WBRT p
Aoyama
JAMA 2006
1-4 MS (months)
8
7.5
NS
1 year overall recurrence rate
76.4%
46.8% <0.001
Neurological death rate
19.3%
22.8%
NS
Brain metastasis
indications
Radiosurgery +/- whole brain radiotherapy
1y KPS > 70
27%
34%
NS
EORTC 22952-26001
Kocher JCO 2011
1-3 Median OS (months)
10.7
10.9
NS
2y relapse at initial site
31%
19%
0.04
2y relapse at new intracranial site
48%
33%
0.02
2y Survival with functional
independance
22.3%
22.6%
NS
28
Clinical