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HDR vs. LDR in prostate cancer

May be radiobiological advantage of

HDR over LDR if prostate α/β ratio is

low

HDR Equipment already available in

most departments and less costly

Randomised trial of external beam radiotherapy

alone or combined with high-dose-rate

brachytherapy boost for localised prostate cancer

Peter J. Hoskin et al. RO 2012; 103(2):217-22.

HDR may have fewer issues with QA:

mis-placement of LDR seeds results in

poor quality implants

Toxicity profile may be more favourable

(shorter duration)