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Photons

p

+

, C

6+

Exponential dose fall off after build up Inverse dose profile with a maximum

energy deposition in the Bragg Peak

Steep distal dose fall off (they stop)

Particle Therapy - Rational

1) Superior physical dose deposition properties

Dose at depth (target) is greater than

dose at surface.

Reference radiation RBE

RBE > 1

2) Higher relative biological effectiveness (RBE)