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Dose localization:

ability to deliver dose precisely and

accurately to a region of interest in the

patient target

(improve geometrical dose shaping )

Focus the dose on the target

(in space and time)

Target definition:

- Tumor delineation

- Organ Motion

- Organ filling

- Tumor shrinkage

Physics problem in RT

The interaction processes of each type of radiation determine

penetration in matter (how much radiation reaches a target)

the amount of dose deposited in the target (tissue)

Dose conformation around the target (dose to the OARs)

delivery technology – treatment planning - imaging

radiation physical properties

– technological inventions

Problem:

Identifying the target location at planning (depends on multimodality

imaging …)

ensuring that the target is geometrically linked correctly to the

beams throughout irradiation!