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Fully automated process based on CBCT

Detection of anatomical changes with CBCT

Input: Manual review of CBCT from 70 pts with NSCLC. Decide on replan or not based

on PTV, Mediastinum, ‘other’ Select lastest CBCT prior to replan or CBCT at fraction 15

were chosen for evaluation.

Dataprocessing: Evaluate density differences between planning CT and CBCT scan

regions of interest. The difference in water equivalent path length along 360 degrees in

each transversal plane was calculated.

Results: The sensitivity for the patients flagged for replanning was 79%, 71%, and 89%

based on anatomical change in the PTV, MED, and the other tissues. No dosimetric data

yet

van den Bosch, Abstract 3rd ESTRO Forum 2015