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No increase of

fibrosis with

Oropharyngeal Ca T2-3, N0-1, n= 356

70 Gy, 35 x 2 Gy, 7w vs 80.5 Gy, 70 x 1.15 Gy, 4-6 h, 7w

LATE EFFECTS FREE

(GRADE 2 OR WORSE)

hyperfractionation

Years

EORTC 22791; Horiot et al.,

Radiother. Oncol.

25: 231-241, 1992