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Moderate hypo-fractionation in prostate RT (<4Gy/fx)

With 3Gy x 20 delivered daily

using IMRT

1. Acute GI toxicity peaks earlier

and higher but resolves quicker

2. Acute GU toxicity peaks earlier

but resolves quicker

3. No difference noted in late

toxicity

Note: HYPRO study

toxicity with

3.4Gyx19 3 times per week

Dearnaley et al. and Incrocci et al

Both Lancet Oncology 2016

DOI.org/10.1016/S1470-2045