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Moderate hypo-fractionation in prostate RT (<4Gy/fx)
With 3Gy x 20 delivered daily
using IMRT
1. Acute GI toxicity peaks earlier
and higher but resolves quicker
2. Acute GU toxicity peaks earlier
but resolves quicker
3. No difference noted in late
toxicity
Note: HYPRO study
toxicity with
3.4Gyx19 3 times per week
Dearnaley et al. and Incrocci et al
Both Lancet Oncology 2016
DOI.org/10.1016/S1470-2045