L0_2016_Athens_Physics_Programme_V6

2898-2899 / 3107

Controversies
 The LQ model. Still valid for big fraction sizes?
Most data are for fraction sizes 1-5 Gy. Controversial if alternative
models required at higher fraction sizes.
 At big fraction sizes the lack of re-oxygenation
would predict worse outcomes than we see.
 Perhaps endothelial damage (apoptosis) important?
 Vascular damage causes secondary tumour cell killing?
 Immune effect?
 How significant is tumour hypoxia – especially
for single fraction treatment.