L0_2016_Athens_Physics_Programme

Second tumor:

contralateral breast cancer (CBC)



40-50%

of all secondary tumors are in the contralateral breast.



At 15y, 10-13%

of patients have developed contralateral tumor (2- to 5-fold

higher than general female population).

data: breast cancer

tumors in patients treated for BREAST CANCER



High risk for CBC is mostly unrelated to RT (

pre-disposition



Conflicting data

on contribution of RT: Some large studies show increased risk

for CBC due to RT, others only for young patients, others don’t show any

enhanced risk



Hormonal treatment with

tamoxifen reduces risk

for CBC by 30-40%

Clinical