454-455 / 3107
Cost function
(
)
(
)(
)
∑
∑
∑
∈
∈
∈
− −
+
+
−
=
2
0
0
2
2
1
1
1
2
0
H 1
1
1
OAR i
i
i
OAR
OAR
OAR i
i
OAR
OAR
Ti
i
T
T
d d d d
n
d
n
d d
n
C
β
β
β
Penalty for not having
uniform dose d
0
(optimising uniformity in target)
Penalty for any
dose to OAR
(minimising the mean of
the OAR)
Penalty for dose above
“tolerance dose d
0
“ in OAR
(keeping max dose below d
0
)
b
Is the
relative weight
factor
H(x)
“Combining all sometimes competing
goals in one cost function …”