544-545 / 3107
Clinically relevant?
Applications
Examples
Intentionally
inhomogeneous
dose distributions
SIB, multiple GTV/CTVs...
Coverage of
concave
PTV with better sparing of OAR
prostate (rectum), head
neck (spinal cord), pelvis
Better coverage of tumors
near critical structures
(also convex)
nasopharyngeal, prostate,
head-neck cancer,…
Steep dose gradient
Conformality
Homogeneity
Potential of IMRT
Re-irradiation
of locally recurrent tumors
spine, head-neck,…
Compensation
of plans
Brachytherapy,
protontheray
11
→
delivery of conventional doses with
↓
toxicity
→
delivery of higher doses without
↑
toxicity