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Biology and caveats
-predisposing factors for late effects
PATIENT-RELATED PROBLEMS
Age (e.g. heart disease)
Other diseases e.g. rheumatoid arthritis,
systemic lupus erythematosus,
dermatomyositis, systemic sclerosis
Surgical complications
Influence from systemic therapy and the timing
between RT and systemic therapy
Future dream: National (or international) clinical
databanks
TECHNIQUE-RELATED PROBLEMS
Dose, fractionation, hot spots, volume,
fotons
versus
electrons, overall treatment
time
Future dream: National (or international)
doseplan databanks
ENDPOINT-RELATED PROBLEMS
Scoring of late morbidity is subjective, e.g. what is a grade 2
fibrosis?
Different scoring systems are used in different studies
Future dream: We all use the same scoring system, take photos
in a standardised way, evaluate the same endpoints and use the
same cutpoints