Diapositive 1

Inter-patient variability in radiotherapy response

Phenotypic and genotypic predictive assays

Focus on RADIOGENOMICS, study of genetic differences in response to RT in

particular

single nucleotide polymorphisms

(SNPs) in selected

candidate

genes

(SNP: an inter-individual variation in the DNA sequence that involves the

substitution of a single nucleotide that occurs in more than 1% of the

population

Candidate gene: a gene whose function indicates that it could be mechanistically

involved in a specific process, such as radiation-damage repair or remodelling)