Diapositive 1

N = 1135

Invasive; < 20 mm; N0; G1 or good prognosis subtype

2x2 clinical trial of factorial design:

•

+/- radiotherapy &

•

+/- tamoxifen

Trial entry was allowed to either comparison or both.

Less local treatment: where is the limit?

Kunkler IH, et al. Lancet Oncol 2015;16:266-73.