1520 / 1674
•
The cumulative toxicity of upfront AI may
explain the lack of OS benefit despite
improvements in DFS.
•
Switching from TAM to AI reduces this toxicity
and is likely the best balance between efficacy
and toxicity.
Hadji P, et al. Breast Cancer Res Treat. 2013;138:185–191
Less local treatment: where is the limit?
Side effects