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Early stage, low risk

(DCIS; T1G1-2; T2G1)

:

LC >>> DM: SX/RT

Early stage, high risk

(T1G3; T2G2-3; N1a)

:

LC: SX/RT

effect

by

Syst.Th.

DM:

Syst.Th

.

importance LC

: need for SX/RT

Late stage

(T3-4; N2a-3)

:

DM >>> LC:

Syst.Th

.

importance of LC: SX/RT

Poortmans P. Lancet. 2014 Jun 21;383(9935):2104-6.

Interaction between local & systemic treatment